Galenos

The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

Original Investigation

The Immunohistochemical Expression of Matrix Metalloproteinases-2 and -9 in Low-Grade Appendiceal Mucinous Neoplasms: May These Neoplasms be Non-Invasive?

Gazi Med J 2018;29(2):123-127 DOI: 10.12996/gmj.2018.34

Abstract

Objective:

Low-grade appendiceal mucinous neoplasms (LAMN) are debated about their potential to cause invasion and pseudomyxoma peritoneii (PMxP). Our aim was to examine these neoplasms by two invasion markers: matrix metalloproteinases- 2 and -9 (MMP).

Methods:

Twenty-eight cases of mucinous adenomas, LAMNs and adenocarcinomas were included. Immunohistochemistry of MMP-2 and -9 were applied and scored.

Results:

Overall, the majority of LAMNs were negative by these two markers.

Conclusion:

LAMNs may not actually have an invasive nature but still they can cause PMxP. These patients should be followed.

Keywords: Appendix, mucinous neoplasm, matrix metalloproteinase