Effects of Non-Pharmacological Interventions on Serum Levels of S100B, NT3 and BDNF in Children with Autism Spectrum Disorder
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Original Investigation

Effects of Non-Pharmacological Interventions on Serum Levels of S100B, NT3 and BDNF in Children with Autism Spectrum Disorder

Gazi Med J 2021;32(3):253-258 DOI: 10.12996/gmj.2022.59
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Abstract

Conclusion:

NPI appears to reverse the increased level of S100B and produce alterations in BDNF and NT3 in ASD patients.

Results:

S100B level was found to be higher in ASD compared to Control group(C) and ASD+NPI. There was no difference between C and ASD+NPI. NT3 was lower in ASD and C than ASD+NPI. Although BDNF was not different between groups, a significant positive correlation between NT3 and BDNF was found in ASD+NPI.

Methods:

All participants were evaluated by to two child and adolescent psychiatrist per DSM-5 criteria. We evaluated 43 cases with ASD and 26 inviduals as a healthy control group between the ages of 0-6 that presented to the outpatient clinic between March 2014 - May 2015.

Objective:

The aim of this study was to examine the effects of non-pharmacological interventions (NPI) on the serum levels of S100B, NT3 and BDNF in patients with autism spectrum disorder (ASD).

Keywords: Autism spectrum disorder, S100B, NT3, BDNF, non-pharmacological interventions