ASSOCIATION OF INCREASED AORTIC PULSE PRESSURE AND AORTIC PULSATILITY WITH CORONARY ARTERY DISEASE AND METABOLIC SYNDROME

Conclusion:

Our findings clearly show that high aortic pulsatility and aortic pulse pressure, which are evidence of atherosclerosis, are encountered as fre-quently or even more frequently in metabolic syndrome as they are in coronary artery disease. Secondly we demonstrated a close relationship between angiog-raphically confirmed coronary artery disease and increased aortic pulse pressu-re, similar to previous reports.

Results:

Hemodynamic parameters like aortic diastolic blood pressure did not differ between the groups. Aortic pulsatility was significantly higher in all 3 patient groups compared to the control group (p< 0.001). This difference was most significant in patient group IV (p= 0.010). Aortic pulse pressure was hig-hest in group II, followed by group III and group IV, compared to the control group (p=0.003).

Materials and Methods:

Two hundred and four consecutive patients (129 men, mean age 56.3±11.1) who underwent cardiac catheterization for the first time were included in the study. All subjects also underwent biochemical in-vestigations and hemodynamic measurements. Hemodynamic parameters like systolic and diastolic aortic pressures were measured during cardiac catheteri-zation using a fluid-filled system in the ascending aorta. Parameters like aor-tic pulsatility and aortic pulse pressure were calculated and compared between four groups: I) control group, who did not have coronary artery disease or me-tabolic syndrome, II) patient group who had only metabolic syndrome, III) pa-tient group who had only coronary artery disease, IV) patient group who had both coronary artery disease and metabolic syndrome.

Purpose:

Aortic pulse pressure and aortic pulsatility are reported to predict car-diovascular risk. Here, we aimed to investigate the association of coronary ar-tery disease and metabolic syndrome with central blood pressure values, which are more reliable than peripheral pressure measurements