Abstract
Purpose:
Sjögren’s syndrome (SS) is characterized by focal lymphocytic infiltration of the salivary, lacrimal, and other exocrine glands. P-Selectin is a cell adhesion molecule that plays critical roles in the homing of the inflammatory cells to the site of inflammation. A soluble form of P-selectin can also be found in the plasma as a circulating protein. The sP-Selectin is also active and could play anti-inflammatory functions by preventing leukocyteendothelium interactions. In this study, we investigated serum levels of sP-Selectin in patients with primary SS
Methods:
Eight patients with primary SS (7 female, 1 male; mean age 44.88 years (35-58)) and 10 healthy subjects (6 female, 4 male; mean age 32.3 years (19 to 44)) were enrolled in this study. sP-Selectin levels were measured using the quantitative sandwich immunoassay technique.
Results:
The mean sP-Selectin levels were 168±94.7 ng/mL and 50.7±29.0 ng/mL for patients with SS and for healthy controls, respectively. sP-Selectin levels were significantly higher in SS patients than in the healthy controls (p<0.01).
Conclusion:
The preliminary data from this pilot study suggested that sP-Selectin might have some place in the pathobiology of SS.
Keywords: Sjögren’s Syndrome, Soluble P-Selectin, Platelet, Endothelium
