ISSN: 2147-2092
BONE MINERAL DENSITY AFTER TREATMENT OF NON-HODGKIN’S LYMPHOMA IN CHILDHOOD
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Original Investigation
VOLUME: 18 ISSUE: 1
P: 26-30
January 2007

BONE MINERAL DENSITY AFTER TREATMENT OF NON-HODGKIN’S LYMPHOMA IN CHILDHOOD

GMJ 2007;18(1):26-30
Aysu Duyan ÇAMURDAN 1
Duyan ÇAMURDAN 2
Alev HASANOĞLU 3
Ceyda KARADENİZ 2
M.Orhun ÇAMURDAN 1
Nurten TÜRKÖZKAN 4
Mustafa ÜNLÜ 5
1. Gazi University, Medical School, Clinic of Pediatrics
2. Professor. Gazi University, Medical School, Department of Pediatric Oncology
3. Professor. Gazi University, Medical School, Department of Pediatric Metabolism
4. Professor. Gazi University, Medical School, Department of Medical Biochemistry
5. Professor. Gazi University, Medical School, Department of Nuclear Medicine Ankara, Turkey
No information available.
No information available
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ABSTRACT

Purpose:

To investigate the side effects of cytotoxic drugs on bone mineral density in children with non-Hodgkin’s lymphoma.

Materials and Methods:

A cross-sectional study was conducted. The patient group was composed of 31 (6 girls and 25 boys) non-Hodgkin’s lymphoma patients who had completed their therapy. The control group was composed of 30 (11 girls and 19 boys) healthy children. The bone mineral density of the vertebrae (BMD-V) and femur (BMD-F) and biochemical parameters of bone turnover were studied in both groups.

Results:

The patient and control groups were statistically similar in terms of age, sex, body weight, height, pubertal status, and laboratory parameters (p >0.05). Mean bone mineral density values (g/m2) in the patient group were lower than those in the control group, but not significantly so (respectively, BMD-V: 0.574±0.188 g/cm2, BMD-F: 0.658±0.191 g/cm2 vs. BMD-V: 0.644±0.158 g/cm2, BMD-F: 0.718±0.128 g/cm2, p>0.05).

Conclusion:

Although there was no significant difference between bone mineral density measurements of the patients and controls, the lower levels of bone density in patients could indicate that the bone mineral density of patients with non-Hodgkin lymphoma was affected by cytotoxic therapy. This should be taken into consideration in the follow-up of such children.

Keywords:
Non-Hodgkin’s lymphoma, bone mineral density, chemothe-rapy, children