ABSTRACT

Cefditoren may be a candidate in the sequential therapy of nosocomial urinary tract infections. These observations need to be supported by clinical studies.

Cefditoren MIC50 and MIC90 values were 1 mg/L and 128 mg/L, respec-tively, and 50% of the isolates were susceptible to cefditoren. The resistance rate was higher among ciprofloxacin resistant strains. In vitro activity of cefditoren was com-parable to that of cefixime, and better than that of the other oral antibiotics, namely ciprofloxacin, TMP-SMZ, cefuroxime, and amoxicillin-clavulanate.

Totally 99 E. coli isolates were studied. Antimicrobial sus-ceptibilities of the strains were tested by agar dilution method for cefditoren, and by disk diffusion method for the other oral antibiotics. The double disk synergy method was used for detection of ESBL activity.

Increasing resistance rates to oral antibiotics among nosocomial urinary Escherichia coli isolates limit the therapeutic options in the sequential therapy of nosocomial urinary tract infections. In this study, the in vitro activities of cefditoren and various oral antibiotics that could be candidates for the sequential therapy of nosocomial UTI were evaluated.