ABSTRACT

Objective:

Gilbert’s syndrome (GS) is a benign condition that is characterized by intermittent mild jaundice due to unconjugated hyperbilirubinemia. The aim of this study was to investigate the effects of increased levels of bilirubin on red cell distribution width (RDW), mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), platelets to lymphocyte ratio (PLR) and other haematological parameters.

Methods:

A total of 1190 young male individuals between the ages of 20-28 who admitted our hospital for occupational examinations were included in this study. Carefully obtained history, detailed physical examination, hematologic and biochemical tests and abdominal ultrasonography were performed. 63 patients diagnosed with Gilbert syndrome and 70 healthy individuals as control group were investigated by comparison and correlation analyzes.

Results:

In the Gilbert syndrome group RDW was 12.0 ± 1.1; MPV was 7,7 ± 0,7 fl; NLR was 2.23 1.07 and PLR was 113.1 ± 31.0. For the control group, the results were as; RDW 11.8 ± 0.9 (p=0.153); MPV 8,2 ± 0,8 fl (p<0.001); NLR 1.84 0.78 (p=0.026) and PLR 102.6 ± 28.1 (p=0.044). There was no difference between the two groups for RDW. MPV was statistically significantly lower and NLR and PLR were higher in Gilbert group than controls. There was a significantly negative correlation between total bilirubin levels and MPV and lymphocyte counts (p <0.05).

Conclusion:

Changes in hematological parameters may play a role in the cardioprotective effect of Gilbert's syndrome.