ABSTRACT
Conclusion:
All three antihypertensive drugs used in this study reduced blood pressure effectively throughout the 24 h period. The only significant difference between their effects is the bradycardia observed after four weeks of therapy with rilmenidine. Knowledge of the individual blood pressure and heart rate profiles of patients with ABPM recordings will help in more effective antihy-pertensive treatments with less adverse effects.
Results:
All three drugs caused significant reductions in 24-hour, daytime, and nighttime means of SBP and DBP, except for nighttime SBP mean by rilmeni-dine. Significant reductions in Mesor (rhythm adjusted mean) values of both SBP and DBP were observed by rhythm analysis of ABPM data with mor-ning administration of cilazapril, a perindopril/indapamide combination (P/I), and rilmenidine. Linear analysis of the data revealed that cilazapril and the P/I combination did not change heart rate, but statistically significant bradycardia was observed after rilmenidine therapy. All three antihypertensives decreased several linear and rhythmic parameters of the rate-pressure product, which is regarded as an indirect measure of myocardial oxygen consumption and load on the heart
Methods:
Thirty-one newly diagnosed, untreated essential hypertensive sub-jects who were not classified as white coat or borderline hypertension parti-cipated in the present study. The subjects were in stages I or II according to the WHO criteria. They were randomly assigned into three groups and were treated with cilazapril 1 mg (n = 10), a perindopril/indapamide combination (2 mg/0.625 mg respectively; n = 10), or rilmenidine 1 mg (n = 11) once daily in the morning for 10 or 12 weeks. The pre- and post-treatment monitor data were analyzed using appropriate methods
Purpose:
Ambulatory blood pressure monitoring (ABPM) devices are used to determine the circadian pattern of blood pressure as well as the efficacy of antihypertensive therapy. This study was designed to compare the effects of cilazapril, a perindopril/indapamide combination (P/I), or rilmenidine on 24-hour, daytime, and nighttime profiles of systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR) parameters obtained by ABPM
