ABSTRACT

Conclusion:

All dialysis patients have an increased oxidative status. A single hemodialysis session with different dialysis membranes does not seem to signi-ficantly change the oxidant or antioxidant levels

Results:

Plasma total antioxidant status levels were lower (1.51±0.2 mmol/l vs. 1.75±0.20 mmol/l p<0.05) and malondialdehyde levels were higher (2.2±1.17 nmol/ml vs. 0.60±0.20 nmol/ml p<0.05) in all dialysis patients compared to the control group. After one hemodialysis session, there were no significant alterations in parameters for either type of dialysis membrane.

Methods:

Fifty-four dialysis patients and 30 healthy controls were included in this study. Ten of the dialysis patients were on continuous ambulatory peritone-al dialysis treatment and the rest were on hemodialysis with either polycarbo-nate membrane (n=10) or hemophan membrane (n=34). Polycarbonate memb-ranes were switched with a vitamin E-coated dialyzer in the subsequent dialysis session. Total antioxidant status and malondialdehyde levels were studied to determine the antioxidant defense capacity and lipid peroxidation, respectively, before and after the dialysis session.

Objective:

To estimate lipid peroxidation and the antioxidant defense capacity of dialysis patients and the effects of different types of dialysis membranes on these parameters