ABSTRACT

Conclusion;

In conclusion, considering that MTHFR C677T polymorphism may be an ethnicity factor in the progression of AD, in our study we found that MTHFR gene polymorphism is not a risk factor for AD in the Turkish Population.

Results;

MTHFR C677T polymorphism T allele frequency was found 32.4% in the patient group and 32.7% in the control group. Genotype frequencies were found to be at similar frequencies in both groups, and no statistically significant difference was found between the groups in terms of genotype and allele frequencies.

Method;

The MTHFR C677T polymorphism was determined using the TaqMan® 5 ′ nuclease assay method in 51 patients who were hospitalized in the psychiatry clinic due to AD and 81 healthy individuals without any chronic and psychiatric diseases.

Objective;

Methylenetetrahydrofolate reductase (MTHFR) enzyme is an important enzyme in folate metabolism. Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism has an effect on plasma homocysteine levels in patients with alcohol use disorder (AD). Recent studies show that homocysteine has toxic effects on dopaminergic neurons. Although there are many studies investigating the relationship between MTHFR C677T polymorphism and AD, the results are contradictory. To the best of our knowledge, the relationship between MTHFR C677T polymorphism and the risk of AD was not investigated in the Turkish population, so this study aimed to investigate the relationship between MTHFR C677T polymorphism and AD in the Turkish population.