ABSTRACT

Conclusion:

With the exception of an isolated increase in Apo-AI levels in CagA negative subjects, eradication of Helicobacter pylori does not seem to have a significant effect on the lipid profile. (Gazi Med J 2012; 23: 122-5)

Results:

Lipid, apolipoprotein, and hsCRP levels did not change after treatment in Group 2. Serum lipids, Apo-B, and Lp(a), and hsCRP levels were also similar in Group 1 after eradication, whereas Apo-AI levels increased signifi-cantly in this group (p=0.002). In subgroup analysis, CagA negative, but not CagA positive, patients in Group 1 had increased Apo-AI levels after successful eradication.

Methods:

Fifty-one patients with positive rapid urease test (33 female, 18 male) were enrolled in the study. Seven-teen (33%) patients were CagA positive. Serum lipids, apolipoproteins, and hsCRP levels were measured at baseline and 3 months after eradication therapy. According to the urea breath test, patients with successful eradication formed Group 1, and those in whom eradication treatment failed constituted Group 2.

Objective:

Helicobacter pylori infection is associated with a modified lipid profile, especially lower HDL cholesterol levels. Cytotoxin Associated Gene A (CagA) positive strains with increased inflammation may further deteriorate lipids levels. Therefore, we investigated the effect of Helicobacter pylori eradication on serum lipid levels, apolipo-proteins, and high sensitive C reactive protein (hsCRP) and its relation with CagA status.