ABSTRACT

Conclusion:

With respect to %IR values, no significant difference was found between diabetic patients and the control group. However, the finding that %IR values were lower both in diabetics compared to controls and in ischemic pati-ents compared to non-ischemic patients is promising for the applicability of qu-antitative analysis of routine MPS data and its possible contribution to the diag-nosis of coronary artery disease

Results:

The calculated %IR values were lower in diabetic patients, although the difference was not statistically significant (p = 0.27). Because MPS revea-led myocardial ischemia in 5 diabetic and 2 control patients, statistical analy-sis was repeated after exclusion of these ischemic patients. However, the result of this analysis was similar (p = 0.27). In the whole study groups, %IR values were significantly lower in patients with myocardial ischemia compared to pa-tients with normal MPS findings (p = 0.02).

Materials and Methods:

We applied single-day rest-stress MPS to 38 diabetic patients over 50 years of age, with DM durations longer than 10 years, and wit-hout hypertension, cigarette smoking, known coronary artery disease, or previ-ous myocardial infarction; and to an age-matched control group of 19 patients with low risk for coronary artery disease. Using left ventricular myocardial co-unts obtained from SPECT data and the injected amounts of Tc-99m sestami-bi, we calculated the relative increase in myocardial counts during exercise in comparison to rest conditions, as %IR, for each patient

Purpose:

To evaluate the additional diagnostic value of a specific quantifica-tion methodology applied to routine MPS in the evaluation of coronary blood flow reserve in a group of patients with type-2 DM.