ABSTRACT
Multiple myeloma is a lymphoproliferative disorder, in which hepatic infiltration of malignant plasma cells may also be seen in later stages of the disease. Herein, we report a case of hepatic myeloma infiltration that was diagnosed by an ultrasonography guided liver biopsy in a multiple myeloma patient. The diagnosis of the hepatic infiltration is important, since it has an impact on the staging and the therapy. Imaging appearances and imaging guided biopsies have an important place in the diagnosis, and therefore in the prognosis of the disease.