ÖZ
Karmaşık bir bozukluk olarak kabul edilen küresel bir sorun olan obezite, çevresel, genetik ve epigenetik faktörlerden etkilenir. Genetik keşifler, epigenetik değişiklikler, beslenme rolleri, hormonal etkiler, inflamasyon ve orta yaşta karın bölgesinde yağlanmanın kesin sorunu öne çıkan faktörlerdir. Bu makale, obezitenin biyolojisiyle ilgili güncel teorilerin bir özetini sunmaktadır. Nöroöstrojenlerin obezite gelişimindeki belirgin rolü de açıklanmıştır. Bu derleme ayrıca, anne obezitesinin fetal karaciğer gelişimini ve daha sonraki çocukluk çağı obezitesini nasıl etkilediğini, anne aşırı beslenmesinin uzun vadeli metabolik etkilerini vurgulayarak incelemektedir. Makale ayrıca, ergenlik obezitesi ve bunun yavruda obezite gelişimine etkisi ile ilgili en son verilerin ve sadece anne obezitesinin değil, baba obezitesinin de yavru üzerindeki etkisinin altını çizmektedir. Nöroöstrojenlerin iştah düzenlemesi ve enerji dengesindeki yeni tanımlanmış rolü, klinik çalışma ve ilaç geliştirme için yeni perspektifler göstermektedir. Ayrıca, obezite için etkili yönetim ve önleme tedbirleri oluşturmak, orta yaşlı bireylerde karın bölgesindeki yağ artışına neden olan mekanizmaları (hormonal değişiklikler, metabolik değişimler ve yaşam tarzı faktörleri gibi) anlamayı gerektirir. Gelişim biyolojisi, genetik ve epigenetikten elde edilen mekanistik bilgilerin klinik uygulaması, obezite bakımında geç aşamadan erken, önleyici ve kişiselleştirilmiş müdahalelere doğru kavramsal bir geçişi desteklemektedir.
Anahtar Kelimeler:
Yağ dokusu öncü hücreleri, nöroöstrojen, epigenetik, FGF19, CP-As
Kaynaklar
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