Determination of Serum Carbohydrate-Deficient Transferrin Levels in Patients with Alcohol Use Disorders, Cirrhosis, Systemic Lupus Erythematosis

1. Gazi Üniversitesi Tıp Fakültesi, Biyokimya Anabilim Dalı, Ankara, Türkiye

2. Gazi Üniversitesi Tıp Fakültesi, Fiziksel Tıp ve Rehabilitasyon Anabilim Dalı, Ankara, Türkiye

3. Gazi Üniversitesi Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, Ankara, Türkiye

4. Gazi Üniversitesi Tıp Fakültesi, Psikiyatri Anabilim Dalı, Ankara, Türkiye

5. Gazi Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenteroloji Bilim Dalı, Ankara, Türkiye

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Received Date: 16.10.2011

Accepted Date: 01.11.2011

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ABSTRACT

Conclusion:

The CDT level are useful as a diagnostic marker in patients with suspected alcohol use disorders, cirrhosis and SLE.(Gazi Med J 2011; 22: 110-2)

Results:

CDT levels in patients with alcohol use disorders, cirrhosis and SLE were determined as significantly high compared to the control group (p1<0.001, p2=0.027, p3=0.001).

Methods:

Twenty-nine patients with alcohol use disorders, 13 patients with cirrhosis, 17 patients with SLE and 31 healthy volunteers were included in the study. Serum CDT levels were measured by high performance liquid chromatography (HPLC) in all patients and healthy volunteers, and the means of the four groups were compared.

Objective:

Carbohydrate-deficient transferrin (CDT) is a glycoprotein that contains sialic acid and is formed by reduction of carbohydrates in transferrin structure. In this study we planned to measure levels of CDT in patients with alcohol use disorders, cirrhosis, systemic lupus erythematosis (SLE). In this way, by looking at the first period, we aimed to show the utility of CDT in these diseases as a marker for early diagnosis.