Effects of Non-Pharmacological Interventions on Serum Levels of S100B, NT3 and BDNF in Children with Autism Spectrum Disorder

1. Gazi University Faculty of Medicine, Department of Child and Adolescent Psychiatry Ankara, Turkey

2. Gazi University Faculty of Medicine, Department of Pharmacology Ankara, Turkey

3. Bilkent City Hospital Department of Psychiatry, Ankara, Turkey

4. Gazi University Faculty of Medicine, Department of Public Health Ankara, Turkey

5. Gazi University Faculty of Medicine, Department of Biochemistry Ankara, Turkey

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Received Date: 29.09.2021

Accepted Date: 03.12.2021

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ABSTRACT

Conclusion:

NPI appears to reverse the increased level of S100B and produce alterations in BDNF and NT3 in ASD patients.

Results:

S100B level was found to be higher in ASD compared to Control group(C) and ASD+NPI. There was no difference between C and ASD+NPI. NT3 was lower in ASD and C than ASD+NPI. Although BDNF was not different between groups, a significant positive correlation between NT3 and BDNF was found in ASD+NPI.

Methods:

All participants were evaluated by to two child and adolescent psychiatrist per DSM-5 criteria. We evaluated 43 cases with ASD and 26 inviduals as a healthy control group between the ages of 0-6 that presented to the outpatient clinic between March 2014 - May 2015.

Objective:

The aim of this study was to examine the effects of non-pharmacological interventions (NPI) on the serum levels of S100B, NT3 and BDNF in patients with autism spectrum disorder (ASD).