Effects of Recurrent Sevoflurane Anesthesia on Erythrocyte Deformability in Experimentally Induced Alzheimer Rats

1. Kütahya Health Sciences University, Faculty of Medicine, Department of Physiology, Kütahya, Turkey

2. Kırıkkale University, Faculty of Medicine Department of Physiology, Kırıkkale, Turkey

3. Gazi University, Faculty of Medicine Department of Physiology, Ankara, Turkey

4. Ankara University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey

5. Gazi University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey

6. Yıldırım Bayazit University Faculty of Medicine, Department of Anesthesiology and Reanimation, Ankara, Turkey

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Received Date: 09.04.2020

Accepted Date: 24.01.2021

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ABSTRACT

Conclusion:

Erythrocyte deformability was increased in the Alzheimer-induced rats; however recurrent sevoflurane anesthesia did not affect erythrocyte deformability.

Results:

The deformability index was significantly increased in Alzheimer-induced rats, but the results for the Alzheimer and Alzheimer + sevoflurane groups were similar. The erythrocyte deformability index was significantly increased in the Alzheimer and Alzheimer + sevoflurane groups (p=0.004 p=0.001 respectively). However, there was no difference in deformability in the sevoflurane group (p= 0.496)

Methods:

A total of 24 Wistar albino rats were divided into four groups: Control, sevoflurane, Alzheimer, and Alzheimer + sevoflurane. The experimental Alzheimer model was prepared by intracerebroventricular injection of streptozotocin at a dose of 3 mg/kg (10 μl) to the Alzheimer and Alzheimer + sevoflurane groups. Sevoflurane (2.3%) was administered to the sevoflurane and Alzheimer + sevoflurane groups 4 weeks after the surgery for 3 days and lasting for 2 hours per day. Blood samples were then collected for deformability measurements.

Objectives:

The aim of this study was to investigate the association between Alzheimer's disease and erythrocyte deformability and to assess whether recurrent sevoflurane anesthesia influenced this association.