ABSTRACT

Langerhans cell histiocytosis is a rare disease, characterized by a clonal proliferation of activated Langerhans cells. The disease has many different clinical presentations and occurs mostly in childhood. Skin involvement is the second most common involvement of langerhans cell histiocytosis after the bone and bone marrow. The disease has four subgroups according to the clinical manifestation and organ involvement; Letterer-Siwe, Hand-Schüller-Christia, eosinophilic granuloma and congenital self-healing langerhans cell histiocytosis. Accurate diagnosis is made by showing langerhans cells by electron microscopy or by detecting CD1a surface antigen by immunohistochemistry. We describe a case of langerhans cell histiocytosis that were falsely diagnosed and treated as seborrheic dermatititis