ABSTRACT

With the exception of an isolated increase in Apo-AI levels in CagA negative subjects, eradication of Helicobacter pylori does not seem to have a significant effect on the lipid profile. (Gazi Med J 2012; 23: 122-5)

Lipid, apolipoprotein, and hsCRP levels did not change after treatment in Group 2. Serum lipids, Apo-B, and Lp(a), and hsCRP levels were also similar in Group 1 after eradication, whereas Apo-AI levels increased signifi-cantly in this group (p=0.002). In subgroup analysis, CagA negative, but not CagA positive, patients in Group 1 had increased Apo-AI levels after successful eradication.

Fifty-one patients with positive rapid urease test (33 female, 18 male) were enrolled in the study. Seven-teen (33%) patients were CagA positive. Serum lipids, apolipoproteins, and hsCRP levels were measured at baseline and 3 months after eradication therapy. According to the urea breath test, patients with successful eradication formed Group 1, and those in whom eradication treatment failed constituted Group 2.

Helicobacter pylori infection is associated with a modified lipid profile, especially lower HDL cholesterol levels. Cytotoxin Associated Gene A (CagA) positive strains with increased inflammation may further deteriorate lipids levels. Therefore, we investigated the effect of Helicobacter pylori eradication on serum lipid levels, apolipo-proteins, and high sensitive C reactive protein (hsCRP) and its relation with CagA status.