ISSN: 2147-2092
P50 Sensory Gating Deficit in Obese Individuals
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Original Investigation
VOLUME: 26 ISSUE: 3
P: 97-100
July 2015

P50 Sensory Gating Deficit in Obese Individuals

GMJ 2015;26(3):97-100
DOI: 10.12996/gmj.2015.30
Mehmet Tecellioğlu 1
Recep Bentli 2
Suat Kamisli 3
1. Department of Neurology, Gözde Medical Center, Malatya, Turkey
2. Department of Internal Medicine, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
3. Department of Neurology, Inonu University Turgut Ozal Medical Center, Malatya, Turkey
No information available.
No information available
Received Date: 13.03.2015
Accepted Date: 28.03.2015
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ABSTRACT

Objective:

Obesity may cause cognitive dysfunctions such as attention, processing speed, memory, and executive functioning. However, little is known about how obesity can affect cognitive functions in obese individuals. Sensory gating shows the early pre-attention period in information processing and is accepted to be the result of the integration of multi-step procedures that can be tested with the double click P50 paradigm. The aim of this study is to investigate changes in cognitive functions with sensory gating in obese individuals

Methods:

A total of 31 obese individuals and age- and sex-matched healthy 24 control subjects were included in the study. The latencies and amplitude P50 waves were measured in the healthy controls and obese individuals. Also the P50 sensory gating was calculated

Results:

We found a significant difference between the obese group and controls regarding the amplitude of the first P50 wave (p<0.048). The obese group showed reduced P50 sensory gating as compared to controls (p<0.004).

Conclusion:

The findings suggest that obese individuals have a sensory gating abnormality seems to be a result of cholinergic dysfunction. This results may help explain congnitive impairment in obese individuals