The Association of MCP-1 Level and MCP-1 -2518 A/G and CCR2 190 G/A Gene Polymorphisms with COPD and Pulmonary Hypertension

1. Sivas Cumhuriyet University, Faculty of Medicine, Department of Medical Genetics, Sivas, Turkey

2. Sivas Cumhuriyet University, Faculty of Medicine, Department of Chest Disease, Sivas, Turkey

3. Sivas Cumhuriyet University, Faculty of Medicine, Department of Cardiology, Sivas, Turkey

4. Sivas Cumhuriyet University, Faculty of Medicine, Department ofEmergency Medicine, Sivas, Turkey

5. Sivas Cumhuriyet University, Faculty of Medicine, Department of Biochemistry, Sivas, Turkey

6. Erzincan Binali Yıldırım University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Erzincan, Turkey

No information available.

No information available

Received Date: 04.07.2019

Accepted Date: 14.03.2020

PDF

Cite

Request

ABSTRACT

Objective:

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by obstructed airflow in the lungs. Pulmonary hypertension (PH) is a common complication of COPD and it is associated with pulmonary vascular remodelling. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines associated with migration of monocytes and macrophages. Both MCP-1 and its receptor CCR2 have been declared to be involved in various diseases. We aimed to research a possible association of MCP-1 level, MCP-1 -2518 A/G and CCR2 190 A/G polymorphisms with COPD and pulmonary hypertension in this study.

Material and methods:

Eighty patients and eighty controls were included in the study. Serum MCP-1 levels were measured by ELISA method. Restriction fragment length polymorphism (RFLP) procedure was used to detect the genotypes of patients and control group.

Results:

MCP-1 levels were found to be significantly higher in COPD patients than in healthy controls (P=0.001) and patients with COPD + PH had higher serum MCP-1 levels than COPD patients (P=0.005). No association was found between MCP-1/CCR2 gene polymorphisms and patient groups (COPD and COPD + PH).

Conclusion:

MCP-1 level seems to be associated with both COPD and pulmonary hypertension. Increased MCP-1 expression may most likely to be involved in the pathogenesis of these diseases.