ABSTRACT

We found that long-term repeated ketamine administration negatively affected erythrocyte deformability. In our study, we think that the results obtained in daily anesthesia will be a guide for repeated administration of ketamine, especially in radiation oncology. However, these findings should be supported by clinical and experimental studies in more detailed and large series.

Ketamine administration was found to increase relative resistance. The erythrocyte deformability index was significantly higher in the ketamine group compared to the saline group (p:0.006).

Twelve 12 week old Wistar Albino male infant rats were randomly divided into two groups. Ketamine group (K), n:6, 50 mg/kg ketamine was administered intraperitoneally at the same time daily for 21 days. Saline group (S), n.6, 50 mg/kg normal saline was administered intraperitoneally at the same time daily for 21 days. After 21 days of administration, all rats were euthanized by intraperitoneal ketamine (100 mg/kg) and taken blood from abdominal aorta. Erythrocytes were obtained from heparinized blood samples. Deformability measurements were performed on erythrocyte suspensions in phosphate buffered saline. For the measurement of erythrocyte deformability, a constant flow filtrometer system was used and the relative resistance was calculated.

Blood rheology, which is affected by many factors, is also known to be affected by drugs used for anesthesia. Therefore, we aimed to investigate the effects of 21-day ketamine administration on erythrocyte deformability in 3-week-old infant rats