ABSTRACT

The procoagulant, anticoagulant and fibrinolytic systems have differences during the neonatal period, and as a result, newborns have a greater predisposition to thrombosis than adults. Thrombosis may cause acute and chronic sequelae during this period. Cerebral palsy, cognitive retardation, epilepsy, hearing defects and death can occur with central nervous system thrombosis; hypertension and renal failure may develop in renal vein thrombosis. In this review, we will discuss the risk factors, clinical manifestations and treatment strategies of thrombosis in the neonatal period which have significant morbidity and mortality. (Gazi Med J 2012; 23: 19-24)